Application problem of sodium alginate in pharmaceutical industry

Editor:Sodium alginate　　　　Source:Sodium alginate manufacturer　　　　2017-05-25 14:31

Sodium alginate is derived frombrown algagenerickelporsea grapeMiddle extractioniodineandmannitolSubsequentby-productIts molecule consists of β -D- mannuronic acid (β -D-mannuronic, m) and α -L- guluronic acid (α -l -L-guluronic, g) press (1→ 4) key connection. The aqueous solution of sodium alginate has high viscosity and has been used as food.Thickener、stabilizing agent、emulgatorWait. Sodium alginate is a non-toxic food, which was included in the United States Pharmacopoeia as early as 1938. Sodium alginate contains a lot of — COO－-,which can show polyanionic behavior in aqueous solution and has certain adhesion, can be used as a drug carrier for treating mucosal tissues. Under acidic conditions, — COO－-into — COOH，ionization degreeWhen decreasing, the hydrophilicity of sodium alginate decreases, the molecular chain shrinks and the pH value increases, — COOH group dissociates constantly, and the hydrophilicity of sodium alginate increases and the molecular chain stretches. Therefore, sodium alginate has obvious pH sensitivity. Sodium alginate can quickly form gel under extremely mild conditions, when Ca2+, Sr2+ and so on are present.cationWhen it exists, Na+ on G units reacts with divalent cations, and G units pile up to form cross-linked network structure, thus forming hydrogel. Sodium alginate formationgelMild conditions, which can avoid sensitive drugs, protein,cellandenzymeInactivation of such active substances. Because of these excellent characteristics, sodium alginate has been widely used in food industry and medicine.

As early as decades ago, natural polysaccharidessodium alginateAs a food additive, it has been used in our lives, and its safety has undoubtedly been recognized by the public. With the development of science and technology, our scientists are going to apply sodium alginate to medical products, and there are many problems to be solved.

　　Sodium alginate materials will also provide new treatment methods for tumors, diabetes and other diseases from a new perspective. Researchers take insulin, an active protein drug, as a model, and sodium alginate as a protease inhibitor. In vitro enzymolysis experiments show that the inhibitor can effectively prevent trypsin from hydrolyzing oral drugs, and its enzyme inhibition efficiency is about 400 times that of existing similar products.

　　"When sodium alginate molecules meet calcium ions, gelation will occur instantly." Sodium alginate with polyanion can be transformed by divalent or trivalent ions, and this ion-dependent gel can maintain a stable gel structure at 0℃~100℃. Based on the ideal gelation performance of sodium alginate, the hydrogel formed has the characteristics of strong water retention, moderate strength and easy processing and molding, and has now become the protagonist in the manufacture of dental imprinting materials, hemostatic dressings and wound dressings.

　　However, because sodium alginate is a material extracted from marine organisms, there are many impurities such as protein, polyphenols and endotoxin brought in by the outside world during the extraction process, which has become the main factor affecting its biocompatibility and restricting its clinical application.

Harmless treatment of sodium alginate wastewater

Sodium alginate, a product with higher value than gold.

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